产品说明: Clone SK3 (See other available formats) Regulatory Status RUO Other Names T4, Leu3a Isotype Mouse IgG1, κ
描述 CD4,也称为 T4,是一种 55 kD 单链 I 型跨膜糖蛋白,在大多数胸腺细胞、T 细胞亚群和单核细胞/巨噬细胞上表达。CD4是Ig超家族的成员,可识别与MHC II类分子相关的抗原,并参与细胞间相互作用、胸腺分化和信号转导。CD4作为HIV的主要受体,与HIV gp120结合。CD4也被证明与IL-16相互作用。 CD4, also known as T4, is a 55 kD single-chain type I transmembrane glycoprotein expressed on most thymocytes, a subset of T cells, and monocytes/macrophages. CD4, a member of the Ig superfamily, recognizes antigens associated with MHC class II molecules and participates in cell-cell interactions, thymic differentiation, and signal transduction. CD4 acts as a primary receptor for HIV, binding to HIV gp120. CD4 has also been shown to interact with IL-16.
Product Details Isotype Control Alexa Fluor® 700 Mouse IgG1, κ Isotype Ctrl Verified Reactivity Human Antibody Type Monoclonal Host Species Mouse Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 700 under optimal conditions.
Concentration Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. Application FC - Quality tested
Recommended Usage Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* Alexa Fluor® 700 has a maximum emission of 719 nm when it is excited at 633 nm / 635 nm. Prior to using Alexa Fluor® 700 conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
View full statement regarding label licenses Excitation Laser Red Laser (633 nm)
Antigen Details Structure Ig superfamily, type I transmembrane glycoprotein, 55 kD Distribution T cell subset, majority of thymocytes,monocytes/macrophages Function MHC class II co-receptor, lymphocyte adhesion, thymic differentiation, HIV receptor Ligand/Receptor MHC class II molecules, HIV gp120, IL-16 Cell Type Macrophages, Monocytes, T cells, Thymocytes, Tregs Biology Area Immunology Molecular Family CD Molecules