BioLegend 338805 APC anti-huma

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BioLegend 338805 APC anti-human CD44
产品简介：
产品品牌：BioLegend
产品货号：338805
产品名称：BioLegend 338805 APC anti-human CD44
产品规格：25 tests

产品说明：
Clone  BJ18 (See other available formats)
Regulatory Status  RUO
Workshop  VI A034
Other Names
Hermes, Pgp-1, H-CAM, HUTCH-1, ECMR III, gp85, Ly-24
Isotype  Mouse IgG1, κ

描述
CD44是一种80-95 kD糖蛋白，也称为Hermes，Pgp1，H-CAM或HUTCH。它在所有白细胞、内皮细胞、肝细胞和间充质细胞上表达。随着B细胞和T细胞被激活或进入记忆阶段，CD44表达从低或中等强度增加到高表达水平。因此，据报道，CD44是记忆细胞亚群的有价值的标记物。CD44是一种粘附分子，参与白细胞附着在内皮细胞上并在内皮细胞上滚动，归巢于外周淋巴器官和炎症部位，以及白细胞聚集。
CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from a low or mid level of intensity to high expression levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.

Product Details
Isotype Control  APC Mouse IgG1, κ Isotype Ctrl
Verified Reactivity  Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus

Antibody Type  Monoclonal
Host Species  Mouse
Immunogen  Normal human PBL
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application  FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser  Red Laser (633 nm)

Antigen Details
Structure
Variable splicing of CD44 gene generates many CD44 isoforms, 85 kD
Distribution
All leukocytes, epithelial cells, endothelial cells, hepatocytes, mesenchymal cells

Function
Leukocyte attachment and rolling on endothelial cells, stromal cells and ECM
Ligand/Receptor   Hyaluronan, MIP-1β, fibronectin, collagen
Cell Type
Endothelial cells, Epithelial cells, Leukocytes, Mesenchymal cells, Mesenchymal Stem Cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Immunology, Stem Cells
Molecular Family    Adhesion Molecules, CD Molecules

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