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- 技术资料
- 库存：
99
- 英文名：
PE anti-human TSLPR (TSLP-R)
- 供应商：
北京云肽生物科技有限公司
BioLegend 322906 PE anti-human TSLPR (TSLP-R)
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
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BioLegend 322906 PE anti-human TSLPR (TSLP-R)
产品简介：
产品品牌：BioLegend
产品货号：322906
产品名称：BioLegend 322906 PE anti-human TSLPR (TSLP-R)
产品规格：100 tests
产品说明：
Clone 1D3 (See other available formats)
Regulatory Status RUO
Other Names
Thymic stromal lymphopoietin protein receptor, cytokine receptor-like 2, CRL2, CRLF2, IL-XR, TSLP-R
Isotype Mouse IgG2a, λ
描述
TSLP-R又称胸腺基质淋巴生成素受体、细胞因子受体样2、CRL2和IL-XR，是一种I型膜受体，与IL-7R形成功能性异二聚体复合物以结合TSLP。TSLP-R包含正确蛋白质折叠所需的WSXWS基序和与JAK结合很重要的box1基序。TSLP-R的预测分子量约为40 kD，并且已经报道了通过交替剪接产生的两种亚型。TSLP-R在骨髓细胞（包括树突状细胞和活化的单核细胞）中优先表达，在T细胞中表达较弱。在心脏、骨骼肌和肾脏组织中也有表达的报道。TSLP与异二聚体功能受体（TSLP-R和IL-7R）结合激活JAK2，STAT3和STAT5以刺激细胞增殖。配体受体相互作用与过敏性疾病中造血系统的发展、树突状细胞成熟以及人Th2记忆T细胞的维持和极化有关。
TSLP-R, also known as thymic stromal lymphopoietin protein receptor, cytokine receptor-like 2, CRL2, and IL-XR, is a type I membrane receptor that forms a functional heterodimeric complex with IL-7R to bind TSLP. The TSLP-R contains a WSXWS motif required for proper protein folding and a box1 motif important for association with the JAKs. TSLP-R has a predicted molecular weight approximately 40 kD, and two isoforms have been reported that are produced by alternative splicing. The TSLP-R is expressed preferentially in myeloid cells including dendritic cells and activated monocytes, and is weakly expressed in T cells. Expression has also been reported in heart, skeletal muscle, and kidney tissues. TSLP binding to the heterodimeric functional receptor (TSLP-R and IL-7R) activates JAK2, STAT3 and STAT5 to stimulate cell proliferation. Ligand receptor interactions haves been implicated in the development of the hematopoietic system, dendritic cell maturation, and the maintenance and polarization of human Th2 memory T cells in allergic diseases.
Product Details
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen Human TSLP-R:Fc protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes
For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 322905/322906) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated anti-mouse IgG (Cat. No. 405303) second step, followed by SAv-PE (Cat. No. 405204)).
Antigen Details
Structure
Type I membrane receptor, forms functional heterodimeric complex with IL-7R to bind TSLP. Contains WSXWS motif required for proper protein folding and a box1 motif that is important for association with the JAKs. Predicted molecular weight approximately 4
Distribution
Expressed preferentially in myeloid cells including dendritic cells and activated monocytes, weakly expressed in T cells. Also expressed in heart, skeletal muscle, and kidney
Function
TSLP binding to functional receptor activates JAK2, STAT3 and STAT5 to stimulate cell proliferation. Has been implicated in the development of the hematopoietic system, dendritic cell maturation, and the maintenance and polarization of human Th2 memory T
Interaction Together with IL-7R binds TSLP
Cell Type Dendritic cells, Monocytes, T cells, Tregs
Biology Area Immunology
Molecular Family Cytokine/Chemokine Receptors
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BioLegend 322906 PE anti-human TSLPR (TSLP-R)
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