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99
- 英文名：
Purified anti-human CD206 (MMR) (Maxpar® Ready)
- 供应商：
北京云肽生物科技有限公司
BioLegend 321127 Purified anti-human CD206 (MMR) (Maxpar® Ready)
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
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BioLegend 321127 Purified anti-human CD206 (MMR) (Maxpar® Ready)
产品简介：
产品品牌：BioLegend
产品货号：321127
产品名称：BioLegend 321127 Purified anti-human CD206 (MMR) (Maxpar® Ready)
产品规格：100 µg
产品说明：
Clone 15-2 (See other available formats)
Regulatory Status RUO
Other Names
MMR (macrophage mannose receptor), MR (mannose receptor), CD206, MRC1
Isotype Mouse IgG1, κ
描述
巨噬细胞甘露糖受体 （MMR） 是一种 162-175 kD 的 I 型膜蛋白，也称为 CD206、MRC1 或甘露糖受体 （MR）。它是一种模式识别受体（PRR），属于C型凝集素超家族。MMR 在巨噬细胞、树突状细胞和肝或淋巴内皮细胞上表达，但不在单核细胞上表达。MMR 可识别一系列含有甘露糖、岩藻糖或 N-乙酰氨基葡萄糖的微生物碳水化合物。MMR介导内吞作用和吞噬作用，诱导巨噬细胞活化和抗原呈递，在宿主防御中起重要作用，并提供先天免疫和适应性免疫之间的联系。
Macrophage mannose receptor (MMR) is a 162-175 kD type I membrane protein also known as CD206, MRC1, or mannose receptor (MR). It is a pattern recognition receptor (PRR) that belongs to C-type lectin superfamily. MMR is expressed on macrophages, dendritic cells, and hepatic or lymphatic endothelial cells, but not on monocytes. MMR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine. MMR mediates endocytosis and phagocytosis, induces activation of macrophages and antigen presentation, plays an important role in host defense, and provides a link between innate and adaptive immunity.
Product Details
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen Purified human mannose receptor
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA.
Preparation
The antibody was purified by affinity chromatography.
Concentration 1.0 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application FC - Quality tested
CyTOF® - Verified
Recommended Usage
This product is suitable for use with the Maxpar® Metal Labeling Kits. For metal labeling using Maxpar® Ready antibodies, proceed directly to the step to Partially Reduce the Antibody by adding 100 µl of Maxpar® Ready antibody to 100 µl of 4 mM TCEP-R in a 50 kDa filter and continue with the protocol. Always refer to the latest version of Maxpar® User Guide when conjugating Maxpar® Ready antibodies.
Application Notes
The 15-2 antibody blocks the interaction of MMR with its ligand, and inhibits mannose receptor-mediated degradation of t-PA by macrophages. Additional reported applications of this antibody (for the relevant formats) include: Western blotting1, blocking of ligand binding1,2, immunofluorescence3, and immunohistochemical staining of *-fixed frozen tissue sections1. The Utra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 321149 and 321150).
Antigen Details
Structure
Type I membrane protein, Pattern Recognition Receptor (PRR) family, C-type lectin superfamily, 162-175 kD
Distribution
Macrophages, dendritic cells, hepatic and lymphatic endothelial cells
Function
Pathogen binding, facilitate phagocytosis and endocytosis, macrophage activation and antigen presentation
Ligand/Receptor Mannose, fucose, N-acetyl glucosamine
Cell Type Dendritic cells, Endothelial cells, Macrophages
Biology Area
Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family CD Molecules
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BioLegend 321127 Purified anti-human CD206 (MMR) (Maxpar® Ready)
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