产品说明: Clone QA16A03 (See other available formats) Regulatory Status RUO Other Names Chemokine (C-X3-C motif) receptor 1, Fractalkine receptor, GPR13, CCRL1, CMKBRL1, CMKDR1, V28 Isotype Mouse IgG1, κ
描述 CX3CR1是一种40kD的G蛋白偶联受体,具有七个跨膜区。CX3CR1由常驻和选择性激活的巨噬细胞(M2)、单核细胞亚群、树突状细胞(DC)、NK细胞、记忆T细胞亚群和肥大细胞表达。CX3CR1参与炎症过程中的细胞募集,并参与细胞粘附和血管外渗。它的配体是CX3CL1,也称为fractalkine或神经肌动蛋白。CX3CR1也是HIV1的辅助受体,该基因的变异导致对HIV的易感性增加。在大脑中,它由神经胶质细胞表达,神经胶质细胞与神经元表达的CX3CL1相互作用。 CX3CR1 is a 40 kD, G-protein coupled receptor, with seven transmembrane regions. CX3CR1 is expressed by resident and alternatively activated macrophages (M2), a subset of monocytes, dendritic cells (DCs), NK cells, a subset of memory T cells, and mast cells. CX3CR1 is involved in cell recruitment during inflammation and participates in cell adhesion and extravasation from blood vessels. Its ligand is CX3CL1, also known as fractalkine or neurotactin. CX3CR1 is also a coreceptor for HIV1 and variations in this gene leads to increased susceptibility to HIV. In the brain, it is expressed by glial cells, which interact with CX3CL1 expressed by neurons.
Product Details Isotype Control APC Mouse IgG1, κ Isotype Ctrl Verified Reactivity Mouse Antibody Type Recombinant Host Species Mouse Immunogen Mouse CX3CR1-transfected cells
Preparation The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. Concentration 0.2 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. Application FC - Quality tested
Recommended Usage Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser Red Laser (633 nm)
Application Notes This recombinant antibody clone is derived from clone SA011F11.
Antigen Details Structure G-protein coupled receptor, 7 transmembrane regions, 40 kD. Distribution Resident and alternatively activated macrophages (M2), subset of monocytes, dendritic cells (DCs), natural killer cells (NK), subset of memory T cells, mast cells, glial cells, and astrocytes.
Function Involved in cell recruitment during inflammation, participates in cell adhesion and extravasation from blood vessels, coreceptor for HIV1. Ligand/Receptor CX3CL1 (fractalkine, neurotactin).
Cell Type Astrocytes, Dendritic cells, Macrophages, Mast cells, Microglia, Monocytes, NK cells, T cells
Biology Area Cell Biology, Immunology, Neuroinflammation, Neuroscience, Neuroscience Cell Markers Molecular Family Cytokine/Chemokine Receptors, GPCR
以下是BioLegend 品牌部分产品,如需其他产品请联系本公司销售。 BioLegend 129611 APC anti-mouse Siglec H 551 25 ug BioLegend 129612 APC anti-mouse Siglec H 551 100 ug BioLegend 129613 PerCP/Cyanine5.5 anti-mouse Siglec H 551 25 ug BioLegend 129708 PE anti-mouse CD199 (CCR9) 9B1 100 ug BioLegend 129710 Alexa Fluor® 647 anti-mouse CD199 (CCR9) 9B1 100 ug BioLegend 129802 Purified anti-mouse CD196 (CCR6) 29-2L17 100 ug BioLegend 129804 PE anti-mouse CD196 (CCR6) 29-2L17 100 ug BioLegend 129808 Alexa Fluor® 647 anti-mouse CD196 (CCR6) 29-2L17 100 ug BioLegend 129809 PerCP/Cyanine5.5 anti-mouse CD196 (CCR6) 29-2L17 25 ug BioLegend 129810 PerCP/Cyanine5.5 anti-mouse CD196 (CCR6) 29-2L17 100 ug BioLegend 129813 APC anti-mouse CD196 (CCR6) 29-2L17 25 ug BioLegend 129815 PE/Cyanine7 anti-mouse CD196 (CCR6) 29-2L17 25 ug BioLegend 129816 PE/Cyanine7 anti-mouse CD196 (CCR6) 29-2L17 100 ug BioLegend 129818 Brilliant Violet 421™ anti-mouse CD196 (CCR6) 29-2L17 500 uL BioLegend 129819 Brilliant Violet 605™ anti-mouse CD196 (CCR6) 29-2L17 50 ug BioLegend 129822 PE/Dazzle™ 594 anti-mouse CD196 (CCR6) 29-2L17 100 ug BioLegend 129823 Brilliant Violet 785™ anti-mouse CD196 (CCR6) 29-2L17 50 ug BioLegend 129905 PE anti-mouse Tim-4 F31-5G3 25 ug BioLegend 130006 PE anti-mouse Tim-4 RMT4-54 100 ug BioLegend 130008 Alexa Fluor® 647 anti-mouse Tim-4 RMT4-54 100 ug BioLegend 130019 PerCP/Cyanine5.5 anti-mouse Tim-4 RMT4-54 25 ug BioLegend 130020 PerCP/Cyanine5.5 anti-mouse Tim-4 RMT4-54 100 ug