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- 英文名：
PerCP/Cyanine5.5 anti-mouse CD193 (CCR3)
- 供应商：
北京云肽生物科技有限公司
BioLegend 144516 PerCP/Cyanine5.5 anti-mouse CD193 (CCR3)
北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国BioLegend公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend虽然成立的时间不长，但它聚集了一批来自PharMingen公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。BioLegend公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 144516 PerCP/Cyanine5.5 anti-mouse CD193 (CCR3)
产品简介：
产品品牌：BioLegend
产品货号：144516
产品名称：BioLegend 144516 PerCP/Cyanine5.5 anti-mouse CD193 (CCR3)
产品规格：100 µg
产品说明：
Clone J073E5 (See other available formats)
Regulatory Status RUO
Other Names
CC CKR3, MIP1-α receptor like-2, eotaxin receptor, MIP1-alpha receptor like-2
Isotype Rat IgG2a, κ
描述
CD193，也称为CC趋化因子受体3（CCR3）、CC CKR3、MIP1-α受体样-2和eotaxin受体，是G蛋白偶联的七跨膜受体家族的成员。它以高亲和力与CC趋化因子eotaxin、eotaxin-2和eotaxin-3结合。CD193也被报道以低亲和力结合RANTES、MCP-3和MCP-4。CD193在小鼠嗜酸性粒细胞、嗜碱性粒细胞、肥大细胞、单核吞噬细胞、血小板、造血祖细胞和角质形成细胞上表达。它被认为在支气管哮喘和过敏性鼻炎等过敏性疾病中发挥作用。CD193也作为HIV-1和HIV-2的共同受体发挥作用，并且eotaxin与CD193的结合已被证明在某些细胞类型中抑制HIV感染。
CD193, also known as CC-chemokine receptor 3 (CCR3), CC CKR3, MIP1-α receptor like-2, and eotaxin receptor, is a member of the G protein-coupled, seven transmembrane receptor family. It binds to the CC chemokines eotaxin, eotaxin-2, and eotaxin-3 with high affinity. CD193 has also been reported to bind RANTES, MCP-3, and MCP-4 with low affinity. CD193 is expressed on mouse eosinophils, basophils, mast cells, mononuclear phagocytes, platelets, hematopoietic progenitor cells, and keratinocytes. It is thought to play a role in allergic diseases such as bronchial asthma and allergic rhinitis. CD193 also function as a co-receptor for HIV-1 and HIV-2, and the binding of eotaxin with CD193 has been shown to inhibit HIV infection in some cell types.
Product Details
Isotype Control PerCP/Cyanine5.5 Rat IgG2a, κ Isotype Ctrl
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen Mouse CCR3-transfectants
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PerCP/Cyanine5.5 under optimal conditions.
Concentration 0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
* PerCP/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.
Additional Product Notes
BioLegend is in the process of converting the name PerCP/Cy5.5 to PerCP/Cyanine5.5. The dye molecule remains the same, so you should expect the same quality and performance from our PerCP/Cyanine5.5 products. Contact Technical Service if you have any questions
Antigen Details
Structure
G-protein coupled, seven transmembrane domain receptor, 356 amino acids
Distribution
Eosinophils, basophils, mast, mononuclear phagocytes, platelets, hematopoietic progenitor, keratinocytes
Function Co-receptor for HIV-1 and HIV-2, allergy
Ligand/Receptor Eotaxin, eotaxin-2, eotaxin-3, RANTES, MCP-3, and MCP-4
Cell Type
Basophils, Eosinophils, Hematopoietic stem and progenitors, Mast cells, Platelets
Biology Area Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
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BioLegend 144516 PerCP/Cyanine5.5 anti-mouse CD193 (CCR3)
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