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- 2025年10月25日
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- 库存：
99
- 英文名：
PE/Cyanine7 anti-mouse CD64 (FcγRI)
- 供应商：
北京云肽生物科技有限公司
北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国BioLegend公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend虽然成立的时间不长，但它聚集了一批来自PharMingen公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。BioLegend公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 139313 PE/Cyanine7 anti-mouse CD64 (FcγRI)
产品简介：
产品品牌：BioLegend
产品货号：139313
产品名称：BioLegend 139313 PE/Cyanine7 anti-mouse CD64 (FcγRI)
产品规格：25 µg
产品说明：
Clone X54-5/7.1 (See other available formats)
Regulatory Status RUO
Other Names FcRI
Isotype Mouse IgG1, κ
描述
CD64是一种72 kD的单链I型糖蛋白，也称为FcγRI和FcRI。CD64是免疫球蛋白超家族的成员，在单核细胞/巨噬细胞、树突状细胞和肥大细胞上表达。IFN-γ刺激可上调其表达。CD64结合IgG免疫复合物。它在抗原捕获、吞噬IgG/抗原复合物和抗体依赖性细胞毒性（ADCC）中发挥作用。
CD64 is a 72 kD single chain type I glycoprotein also known as FcγRI and FcRI. CD64 is a member of the immunoglobulin superfamily and is expressed on monocytes/macrophages, dendritic cells, and mast cells. The expression can be upregulated by IFN-γ stimulation. CD64 binds IgG immune complex. It plays a role in antigen capture, phagocytosis of IgG/antigen complexes, and antibody-dependent cellular cytotoxicity (ADCC).
Product Details
Isotype Control PE/Cyanine7 Mouse IgG1, κ Isotype Ctrl
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Mouse
Immunogen BALB/c mouse FcγRI-human IgG Fc fusion protein.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
Concentration 0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Antigen Details
Structure Ig superfamily, type I glycoprotein, 72 kD
Distribution
Monocytes, macrophages, mast cells, dendritic cells
Function Phagocytosis, ADCC
Ligand/Receptor IgG
Cell Type Dendritic cells, Macrophages, Mast cells, Monocytes
Biology Area Immunology, Innate Immunity
Molecular Family CD Molecules, Fc Receptors
以下是BioLegend 品牌部分产品，如需其他产品请联系本公司销售。
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文献和实验Cell Surface Immunofluorescence Staining Protocol
. In the mouse, purified anti-mouse CD16/CD32 antibody specific for Fcγ R III/II (BioLegend Cat. #101302, clone 93) can be used to block nonspecific staining of antibodies. In this case, block Fc receptors by pre-incubating cells with 5-10 μg/ml purified anti-CD
MHC及其相关分子 MHCⅠ类抗原：α链、β2M MHCⅡ类抗原：α、β链 β2M相关分子：CD1、Qa、TL 免疫球蛋白受体 PolyIgR(pIgR) IgG Fc段受体：FcγRⅠ（CD64）、FcγRⅡ、FcγRⅢ（CD16） Ige Fc段受体：FcεRIα链
在细胞膜上，而PDGFR胞浆区含有543个氨基酸残基，并具有酪氨酸激酶的结构。除CD4第一个结构域和N-CAM分子外，Ig超家族中的一个结构域通常由一个外显子所编码。有些Ig超家族成员的基因连锁在一起，如Thy-1，N-CAM，CD3γ、δ、ε链的基因在11q23。Ig Fc段受体FcγRⅠ、FcγRⅡ、FcγRⅢ和FcεRⅠα链基因在1q23-q24。 根据IGSF结构域中Ig折叠方式、两个半胱氨酸之间氨基酸残基的数目以及IgV区或C区同源性的程度，IGSF结构域可分为V组、C1组和C2
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