BioLegend 131507 PE anti-mouse

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BioLegend 131507 PE anti-mouse CD155 (PVR)
产品简介：
产品品牌：BioLegend
产品货号：131507
产品名称：BioLegend 131507 PE anti-mouse CD155 (PVR)
产品规格：25 µg

产品说明：
Clone  TX56 (See other available formats)
Regulatory Status  RUO
Other Names  PVR (poliovirus receptor) homolog
Isotype  Rat IgG2a, κ

描述
小鼠CD155，也称为脊髓灰质炎病毒受体同源物（PVR），是免疫球蛋白样粘附受体亚家族的创始成员。小鼠CD155除了存在于上皮细胞外，在多种造血来源的细胞上表达。CD155与CD226和CD96的结合诱导NK细胞和CTL的细胞毒性。
Mouse CD155, also known as homolog of polivirus receptor (PVR), is the founding member of a subfamily of immunoglobulin-like adhesion receptors (nectins). Mouse CD155 is expressed on a wide variety of cells of hematopoietic origin apart from its existence on the epithelial cells. The engagement of CD155 with CD226 and CD96 induces cytotoxicity of NK cells and CTL.

Product Details
Isotype Control  PE Rat IgG2a, κ Isotype Ctrl
Verified Reactivity  Mouse
Antibody Type  Monoclonal
Host Species  Rat
Immunogen  CD155 transfectants
Formulation  Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation  The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration  0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application  FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser  Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Antigen Details
Structure  70 kd immunoglobulin-like molecule with three Ig-like domains.
Distribution
CD155 is expressed at cell junctions on the primary vascular endothelial cells. Moreover, mouse CD155 is highly expressed on DP thymocytes and expression level is dropped in peripheral single positive CD4 and CD8 T cells. CD155 can be detected on T reg, other activated T cells and on NKT cells. Resident monocytes express moderate amount of CD155, but upregulated its expression during inflammation. Other cells, such as IEL, neutrophils and subsets of B cells were found to express CD155 to varying extents.++

Function
Apart from its function of adhering junction among contacting epithelial cells, the interaction of DNAM-1 (CD226) with its ligands CD155 and CD112 (nectin 2) induces cytotoxcity of NK cells and CD8 T cells and cytokine secretion. +
Ligand/Receptor  CD226 (DNAM-1), CD96
Cell Type  B cells, Endothelial cells, Neutrophils, Thymocytes, Tregs
Biology Area  Immunology
Molecular Family  Adhesion Molecules, CD Molecules, Immune Checkpoint Receptors

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