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- 库存：
99
- 英文名：
PE anti-mouse CD155 (PVR)
- 供应商：
北京云肽生物科技有限公司
BioLegend 131507 PE anti-mouse CD155 (PVR)
北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国BioLegend公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend虽然成立的时间不长，但它聚集了一批来自PharMingen公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。BioLegend公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 131507 PE anti-mouse CD155 (PVR)
产品简介：
产品品牌：BioLegend
产品货号：131507
产品名称：BioLegend 131507 PE anti-mouse CD155 (PVR)
产品规格：25 µg
产品说明：
Clone TX56 (See other available formats)
Regulatory Status RUO
Other Names PVR (poliovirus receptor) homolog
Isotype Rat IgG2a, κ
描述
小鼠CD155，也称为脊髓灰质炎病毒受体同源物（PVR），是免疫球蛋白样粘附受体亚家族的创始成员。小鼠CD155除了存在于上皮细胞外，在多种造血来源的细胞上表达。CD155与CD226和CD96的结合诱导NK细胞和CTL的细胞毒性。
Mouse CD155, also known as homolog of polivirus receptor (PVR), is the founding member of a subfamily of immunoglobulin-like adhesion receptors (nectins). Mouse CD155 is expressed on a wide variety of cells of hematopoietic origin apart from its existence on the epithelial cells. The engagement of CD155 with CD226 and CD96 induces cytotoxicity of NK cells and CTL.
Product Details
Isotype Control PE Rat IgG2a, κ Isotype Ctrl
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen CD155 transfectants
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration 0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Antigen Details
Structure 70 kd immunoglobulin-like molecule with three Ig-like domains.
Distribution
CD155 is expressed at cell junctions on the primary vascular endothelial cells. Moreover, mouse CD155 is highly expressed on DP thymocytes and expression level is dropped in peripheral single positive CD4 and CD8 T cells. CD155 can be detected on T reg, other activated T cells and on NKT cells. Resident monocytes express moderate amount of CD155, but upregulated its expression during inflammation. Other cells, such as IEL, neutrophils and subsets of B cells were found to express CD155 to varying extents.++
Function
Apart from its function of adhering junction among contacting epithelial cells, the interaction of DNAM-1 (CD226) with its ligands CD155 and CD112 (nectin 2) induces cytotoxcity of NK cells and CD8 T cells and cytokine secretion. +
Ligand/Receptor CD226 (DNAM-1), CD96
Cell Type B cells, Endothelial cells, Neutrophils, Thymocytes, Tregs
Biology Area Immunology
Molecular Family Adhesion Molecules, CD Molecules, Immune Checkpoint Receptors
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BioLegend 131507 PE anti-mouse CD155 (PVR)
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