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- 文献和实验
- 技术资料
- 库存:
99
- 英文名:
Biotin anti-mouse TER-119/Erythroid Cells
- 供应商:
北京云肽生物科技有限公司
北京云肽生物科技有限公司作为BioLegend的特约经销商,为广大客户提供原装正品,货期短,折扣好的服务准则。
美国BioLegend公司位于美国加州,致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend虽然成立的时间不长,但它聚集了一批来自PharMingen公司的专业人士,建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势,以及与世界知名实验室和研究所的良好合作关系,以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。BioLegend公司以其专业技术力量为保证,提供各种质量卓越的产品,并不断地开发新产品,以满足飞速发展的生命科学研究的需要。
BioLegend 116203 Biotin anti-mouse TER-119/Erythroid Cells
产品简介:
产品品牌:BioLegend
产品货号:116203
产品名称:BioLegend 116203 Biotin anti-mouse TER-119/Erythroid Cells
产品规格:50 µg
产品说明:
Clone TER-119 (See other available formats)
Regulatory Status RUO
Other Names Ly-76
Isotype Rat IgG2b, κ
描述
TER-119抗原是一种52kD糖蛋白a相关蛋白,也称为Ly-76。TER-119是一种红系特异性抗原,在早期前红细胞至成熟红细胞上表达,但在红系集落形成细胞(BFU-E,成细胞单位红系,或CFU-E,集落形成单位红系)上不表达。
The TER-119 antigen is a 52 kD glycophorin A-associated protein, also known as Ly-76. TER-119 is an erythroid-specific antigen expressed on early proerythroblasts to mature erythrocytes, but not on erythroid colony-forming cells (BFU-E, blast-forming unit erythroid, or CFU-E, colony-forming unit erythroid).
Product Details
Isotype Control Biotin Rat IgG2b, κ Isotype Ctrl
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen Day-14 fetal liver cells from a C57BL/6 mouse
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
Concentration 0.5 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes
The TER-119 antibody is useful for distinguishing erythrocytes and cells in the erythroid lineage. Additional reported applications (for the relevant formats) include: immunoprecipitation1, Western blotting1, complement-mediated cytotoxicity3, and immunohistochemical staining of *-fixed frozen sections and formalin-fixed paraffin-embedded sections. Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 116253-116258).
Antigen Details
Structure Associated with glycophorin A, 52 kD
Distribution
Early proerythroblast to mature erythrocyte, but not BFU-E and CFU-E
Cell Type Erythrocytes
Biology Area Immunology
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细胞或外源性注射 ARTN 同样可以减弱放疗和 PD-L1 阻滞的抗肿瘤作用。上述的结果表明免疫治疗和放疗的治疗作用部分依赖于它们对 Ter 细胞的抑制。 图片来源:Sci. Transl. Med 同样的,破坏 Ter/ARTN 轴能够恢复甚至增加放疗和抗 PD-L1 治疗的疗效。通过使用 anti-Ter119 抗体,将小鼠体内 Ter 细胞耗尽,这显著促进了放疗和抗 PD-L1 治疗的作用。接下来的研究也表明阻断 ARTN 能增强抗肿瘤治疗效果。因此,Ter 细胞耗尽、ARTN 中和都能够
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