BioLegend 101106 FITC anti-mou

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BioLegend 101106  FITC anti-mouse CD11a
产品简介：
产品品牌：BioLegend
产品货号：101106
产品名称：BioLegend  101106  FITC anti-mouse CD11a
产品规格：500 µg

产品说明：
Clone  M17/4 (See other available formats)
Regulatory Status  RUO
Other Names  αL integrin, LFA-1 α subunit, Ly-15, Ly-21, ITGAL
Isotype  Rat IgG2a, κ

描述
CD11a 是一种 180 kD 糖蛋白，也称为 αL 整合素、LFA-1 α、Ly-15 或 Ly-21。它是整合素家族的成员，主要在淋巴细胞、单核细胞/巨噬细胞和粒细胞上表达。与CD18结合，CD11a / CD18复合物形成LFA-1。CD11a通过结合其配体ICAM-1（CD54），ICAM-2（CD102）和ICAM-3（CD50）在细胞间粘附和共刺激中起重要作用。
CD11a is a 180 kD glycoprotein, also known as αL integrin, LFA-1 α, Ly-15, or Ly-21. It is a member of the integrin family, primarily expressed on lymphocytes, monocytes/macrophages, and granulocytes. In association with CD18, the CD11a/CD18 complex forms LFA-1. CD11a plays an important role in intercellular adhesion and costimulation by binding its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50).

Product Details
Isotype Control   FITC Rat IgG2a, κ Isotype Ctrl
Verified Reactivity   Mouse
Antibody Type  Monoclonal
Host Species   Rat
Immunogen   C57BL/6 mouse splenic secondary cytotoxic T cells
Formulation   Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation   The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions
.Concentration  0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze
.Application   FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes
The M17/4 antibody can block CD11a-mediated cellular adhesion. Additional reported applications of this antibody (for the relevant formats) include: immunoprecipitation1,2, in vitro blocking of cell-cell adhesion1,2 and FOXP3 expression5, and immunohistochemical staining of *-fixed frozen sections3. The M17/4 antibody does not block the binding of 2D7 antibody (Cat. No. 101002) to CD11a. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 101110). For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 101118) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin <0.01 EU/µg).

Antigen Details
Structure   Integrin family, associates with integrin β2 (CD18), 180 kD
Distribution
Lymphocytes, granulocytes, monocytes, macrophages
Function  Cellular adhesion
Ligand/Receptor  ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50)
Cell Type  Granulocytes, Lymphocytes, Macrophages, Monocytes, Tregs
Biology Area  Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Molecular Family  Adhesion Molecules, CD Molecules

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