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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
DPP4; ADABP; ADCP2; DPPIV; TP103
- 抗体英文名：
DPP4; ADABP; ADCP2; DPPIV; TP103
- 靶点：
-
- 浓度：
>95% by SDS-PAGE
- 应用范围：
-
- 宿主：
Human
- 适应物种：
-
- 保质期：
Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
- 抗原来源：
-
- 目录编号：
-
- 级别：
-
- 库存：
现货
- 供应商：
爱必信(上海)生物科技有限公司
- 标记物：
-
- 克隆性：
-
- 保存条件：
Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
- 形态：
Lyophilized Powder
- 亚型：
-
- 免疫原：
-
- 规格：
100ug/500ug
| 规格： | 100ug | 产品价格： | ￥4500.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥15000.0 |
| 概述 | |
| 别名 | DPP4; ADABP; ADCP2; DPPIV; TP103 |
| 种属 | Human |
| 来源 | HEK293 |
| 分子量 | 105-120 kDa |
| 外观 | Lyophilized Powder |
| 形态 | Lyophilized from PBS, pH7.4 |
| 性能 | |
| 序列 | PKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKE YKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV FSCSVMHEALHNHYTQKSLSLSPGKDDDDKNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSI NDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEE VFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERI SLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLY YISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNE TKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIA IWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVG VDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP |
| 纯度 | >95% by SDS-PAGE |
| 内毒素水平 | <0.1EU/ug |
| 溶解方法 | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| 储存/保存方法 | Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles. |
| 靶标 | |
| 背景说明 | Dipeptidyl peptidase 4 (DPPIV, also known as CD26) is an approximately 110 kDa serine exopeptidase that releases Xaa-Pro or Xaa-Ala dipeptides from the N-terminus of oligo- and polypeptides. Mature human DPPIV consists of a 6 amino acid (aa) cytoplasmic tail, a 22 aa transmembrane segment, and a 738 aa extracellular domain (ECD) that contains the catalytic active site. DPPIV is expressed as a noncovalent homodimer on the surface of epithelial cells, endothelial cells, and activated lymphocytes, and it can be released by MMP mediated shedding. It regulates immune and endocrine function through the cleavage of multiple chemokines, growth factors, and peptide hormones. CD26/dipeptidyl peptidase (DPP) 4 is a membrane-bound protein found in many cell types of the body, and a soluble form is present in body fluids. There is longstanding evidence that various primary tumors and also metastases express CD26/DPP4 to a variable extent. By cleaving dipeptides from peptides with a proline or alanine in the penultimate position at the N-terminus, it regulates the activity of incretin hormones, chemokines and many other peptides. Due to these effects and interactions with other molecules, a tumor promoting or suppressing role can be attributed to CD26/DPP4. DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others. DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established. |
| Accession | P27487 |
| 参考文献 | |
| 参考文献 | 1、Klemann C. et al. (2016) Cut to the chase: a review of CD26/dipeptidyl peptidase-4’s (DPP4) entanglement in the immune system. Clin Exp Immunol. 185(1): 1-21.2、Mortier A. et al. (2016) CD26/dipeptidylpeptidase IV—chemokine interactions: double-edged regulation of inflammation and tumor biologyJ. Leukoc Biol. 99(6): 955-969.3、Rohrborn D. et al. (2014) Shedding of dipeptidyl peptidase 4 is mediated by metalloproteases and up-regulated by hypoxia in human adipocytes and smooth muscle cells. FEBS Lett. 588(21): 3870-3877.4、Enz N. et al. (2019) CD26/DPP4 - a potential biomarker and target for cancer therapy. Pharmacol Therapeiut. 198: 135-159. |
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