Sino Biological GPRC5D Protein Mouse Recombinant Flag Tag VLP gprc5d

内毒素< 1.0 EU per μg protein as determined by the LAL method.
生物活性Recombinant Mouse GPRC5D-VLP (Full Length) Protein (Flag Tag) (Cat: 5A4669-M25H) at 5 μg/mL (100 μL/well) can bind Anti-Human GPRC5D Antibody, Human IgG1, the EC50 is 2.84 ng/mL.
蛋白构建A DNA sequence encoding the Mouse GPRC5D (Q9JIL6-2) (Met1-Cys300) was expressed.
表达宿主HEK293 Cells
种属Mouse
预测 N 端Met 1
分子量The recombinant Mouse GPRC5D consists of 313 amino acids and has a predicted molecular mass of 35.8 kDa.
缓冲液Supplied as sterile 50mM Hepes, 150mM NaCl, 10% Trehalose, pH 7.2.
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
运输方式It is supplied and shipped as liquid with dry ice.
稳定性 & 储存条件Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -70℃ or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

GPRC5D 背景信息
Orphan G-protein-coupled receptor family C group 5 member D (GPRC5D) has seven transmembrane segments forming the core of the receptor, as well as an intracellular C-tail and an extracellular N-terminal domain. GPRC5D is highly and selectively expressed on the surface of CD138+ multiple myeloma (MM) cells, whereas in normal tissues, a much lower expression is limited to plasma cells and certain hard keratinizing tissues. This makes GPRC5D a promising marker for monitoring tumor load and a target antigen for MM-specific T cell-engaging therapies such as bispecific antibodies and CAR-T cells.