Mirvetuximab soravtansine

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Mirvetuximab soravtansine

CAS No. : 1453084-37-1

MCE 国际站：Mirvetuximab soravtansine

产品活性：Mirvetuximab soravtansine (IMGN853) 是一种抗体药物偶联物 (ADC)，由细胞毒性 maytansoid DM4 组成，共价连接到人源化单克隆抗体 M9346A。Mirvetuximab soravtansine 选择性结合叶酸受体1 (FOLR1)。Mirvetuximab soravtansine 具有抑制生长和增强 DNA 损伤的抗增殖作用。

研究领域：Antibody-drug Conjugate/ADC Related

作用靶点：Antibody-Drug Conjugates (ADCs)

In Vitro: Mirvetuximab soravtansine (IMGN853; 8 nM; 6 h; IGROV-1 cells) combined with Carboplatin (HY-17393) promotes synergistic growth inhibitory effects and cell cycle perturbations in vitro.

In Vivo: Mirvetuximab soravtansine (IMGN853; 5 mg/kg; i.v.; female severe combined immunodeficient (SCID) mice with patient-derived xenografts) potentiates the antitumor activity of Carboplatin in vivo.

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