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- 2025年12月05日
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MYC-RIBOTAC
MCE 国际站：MYC-RIBOTAC
产品活性：MYC-RIBOTAC 是一种核糖核酸酶靶向降解剂 (ribonuclease-targeting chimera , RIBOTAC)，靶向 MYC 内部核糖体进入位点 internal ribosome entry site (IRES)。 MYC-RIBOTAC 含有一个 MYC mRNA 结合组分和一个具有募集和局部激活 RNA 酶 L1 作用的小分子。MYC-RIBOTAC 降低 MYC 的 mRNA 和蛋白表达水平，诱导细胞凋亡(apoptosis)，可用于抗肿瘤研究。
研究领域：Apoptosis
In Vitro: MYC-RIBOTAC (0-10 μM; 48 hours) decreases the abundance of MYC mRNA and protein levels in HeLa cells in a dose-dependent and RNase L dependent manner.
MYC-RIBOTAC (0-10 μM; 48 hours) has antiproliferative and induce-apoptotic effects in HeLa cells and Namalwa cells.
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文献和实验Chromatin Immunoprecipitation Assays for Myc and N-Myc
Myc and N-Myc have widespread impacts on the chromatin state within cells, both in a gene-specific and genome-wide manner. Our laboratory uses functional genomic methods including chromatin immunoprecipitation (ChIP), ChIP-chip
Myc is a transcriptional coordinator of a wide range of intracellular and extracellular processes required for cell proliferation. These processes are tightly regulated in physiological conditions but hijacked when Myc is oncogenically
In this chapter, we discuss in detail two essential methods used to evaluate the interaction of Myc with another protein of interest: co-immunoprecipitation (Co-IP) and in vitro pull-down assays. Co-IP is a method that, by immunoaffinity
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