- ￥4150 - 7150
- 爱必信(absin)
- abs823359
- 上海
- 2025年07月15日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 库存：
现货
- 英文名：
Leptomycin B；Elactocin；LMB；Mantuamycin
- CAS号：
87081-35-4
- 保质期：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 供应商：
爱必信(上海)生物科技有限公司
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 规格：
5mg/10mg
| 规格： | 5mg | 产品价格： | ￥4150.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥7150.0 |
| 产品描述 | |
| 描述 | Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle. |
| 来源 | Bacterium/Streptomyces sp |
| 纯度 | ≥98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 来普霉素B; Elactocin；LMB；Mantuamycin |
| 外观 | White to off-white powder |
| 可溶性/溶解性 | DMSO : 100 mg/mL (184.94 mM; Need ultrasonic) |
| 生物活性 | |
| 靶点 | CRM1/exportin 1 |
| In vitro(体外研究) | Leptomycin B (LMB) is very potent in vitro against various cancer cell lines (IC50 values in the 0.1 to 10 nM range). Leptomycin B (LMB) inhibits SiHa, HCT-116, and SKNSH cells with IC50s of 0.4, 0.3 and 0.4 nM for a 72 hour exposure, respectively. Leptomycin B (LMB) (0.5 nM) displays a synergistic effect on Gefitinib (0–32 μM)-induced cytotoxicity in A549 and H460 cell line. The simultaneous treatments of Gefitinib (0–32 μM) and Leptomycin B (0.5 nM) show synergistic cytotoxic effect on A549 as compared to Gefitinib alone at both 24 and 48 hours. |
| In vivo(体内研究) | Leptomycin B (LMB) is poorly tolerated in vivo. Maximum tolerated dose (MTD) is 2.5 mg/kg for LMB (single i.v.) in HCT-116 tumor–bearing mice.The limited in vivo efficacy of Leptomycin B is due to off-target effects because our nuclear export inhibitors (NEIs) retain the potent inhibition of CRM1, but are clearly better tolerated in vivo. |
分子结构图：
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验新霉素 B neomycinB 由放线菌产生的氨基糖苷类的抗菌素。与链霉素相似，对结核菌和其它细菌具有抗菌作用。作用机理也相类似，与细菌 30S核糖体结合，使 mRNA发生解读错误，从而阻止蛋白质的合成。
1,是主要的出核介导物。这种蛋白与出核蛋白上的NES序列结合并将其转运至核孔的出核部分。 Leptomycin B是从链霉菌中分离出来的一种不饱和支链脂肪酸，其末端带有内酯环。除了具有抗生素、抗真菌、抗肿瘤活性外，同时它还是一种有效的CRM1介导的出核的抑制剂。Leptomycin B和CRM1的一个保守的半胱氨酸巯基形成共价化合物，阻止CRM1和出核的目标蛋白的NES序列相互作用。这种共价作用使Leptomycin B成为这一过程不可逆的抑 制剂。已知有很多蛋白的运输，包括
35Analysis of Single Nucleotide Polymorphisms in the Interleukin-1B Gene Using 5 Nuclease Assays
Interleukins are soluble peptide molecules that mediate the interaction between immunocompetent and haematopoietic cells and between the immune and neuroendocrine systems (1 ). They are produced by a variety of activated cells and exert
技术资料暂无技术资料 索取技术资料
