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- 详细信息
- 文献和实验
- 技术资料
- 英文名:
KMS-11
- 库存:
100
- 供应商:
中乔新舟
- 品系:
细胞系
- 运输方式:
常温
- 年限:
液氮长期
- 生长状态:
半贴半悬
- 规格:
T25
|
产品名称 |
KMS-11人骨髓瘤细胞 |
|
货号 |
ZQ0840 |
|
产品介绍 |
KMS-11是一种人多发性骨髓瘤克隆细胞系,源自一名67岁患有骨髓瘤的女性的胸腔积液。在癌症研究中有着广泛的应用,包括药物筛选、病理机制研究和基因功能分析。它们是理解骨髓瘤发展和寻找新治疗方法的重要工具。 |
|
种属 |
人 |
|
性别/年龄 |
女/67岁 |
|
组织 |
胸腔积液 |
|
疾病 |
多发性骨髓瘤 |
|
细胞类型 |
肿瘤细胞 |
|
形态学 |
淋巴样细胞 |
|
生长方式 |
半贴半悬 |
|
倍增时间 |
大约36 hours (PubMed=2519219); 70 hours (PubMed=25984343); 50 hours (Note=Lot 03062008), ~2 days (Note=Lot 10142009), ~31 hours (Note=Lot 10072016), ~39 hours (Note=Lot 10222021) (JCRB=JCRB1179) |
|
培养基和添加剂 |
RPMI-1640(品牌:中乔新舟 货号:ZQ-200)+10%胎牛血清(中乔新舟 货号:ZQ0500)+1%P/S(中乔新舟 货号:CSP006) |
|
推荐完全培养基货号 |
ZM0840 |
|
生物安全等级 |
BSL-1 |
|
培养条件 |
95%空气,5%二氧化碳;37℃ |
|
STR位点信息 |
Amelogenin: X CSF1PO: 13 D3S1358: 15 D5S818: 10,12 D7S820: 11,12 D8S1179: 13 D13S317: 12 D16S539 :9,13 D18S51: 13,14 D21S11: 28,30 FGA: 22,24 Penta D: 11,12 Penta E: 15,16 TH01: 6,9 TPOX: 12 vWA :17,18 |
|
抗原表达/受体表达 |
*** |
|
基因表达 |
*** |
|
保藏机构 |
JCRB; JCRB1179 |
|
供应限制 |
仅供科研使用 |
上海中乔新舟生物科技有限公司成立于2011年,历经十多年发展,主要专注于细胞生物学产品的研究和开发,专注于为药企、各类科研机构及CRO企业提供符合标准规范的细胞培养服务、细胞培养基、细胞检测试剂盒、细胞培养试剂,胎牛血清和细胞生物学技术服务等。
公司一直致力于为高等院校、研究机构、医院、CRO及CDMO企业提供细胞培养完整解决方案,这些产品旨在满足细胞培养的多样需求,确保实验和研究的有效进行。引用中乔新舟(ZQXZBIO)产品和服务的文献超数千篇。

产品服务
细胞资源:原代细胞、细胞株、干细胞、示踪细胞、耐药株细胞、永生化细胞等基因工程细胞。
试剂产品:胎牛血清、完全培养基(适用于原代细胞及细胞株)、无血清培养基、基础培养基、细胞转染试剂、重组因子、胰酶和双抗等等细胞培养所有实验相关产品。
技术服务:稳转株构建、原代细胞分离、特殊培养基定制服务、细胞检测等。

目前产品已经畅销国内30多个省市,与客户建立长期的合作伙伴关系,共同实现成功。全体员工将不懈努力,继续为科研人员提供优良的产品和服务,致力成为全球细胞培养领域的参与者。

企业愿景
致力于成为国内细胞培养基产业的佼佼者,生物医药领域上游原材料的优良提供商。
企业使命
成长为专业细胞系及原代细胞培养供应商、专业细胞培养基及培养试剂生产商。
企业荣誉


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文献和实验
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Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
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Drexler H.G.
The leukemia-lymphoma cell line factsbook.
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Chesi M., Brents L.A., Ely S.A., Bais C., Robbiani D.F., Mesri E.A., Kuehl W.M., Bergsagel P.L.
Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma.
Blood 97:729-736(2001)
PubMed=15215163; DOI=10.1016/S0002-9440(10)63276-2
Inoue J., Otsuki T., Hirasawa A., Imoto I., Matsuo Y., Shimizu S., Taniwaki M., Inazawa J.
Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma.
Am. J. Pathol. 165:71-81(2004)
PubMed=16956823
Bataille R., Jego G., Robillard N., Barille-Nion S., Harousseau J.-L., Moreau P., Amiot M., Pellat-Deceunynck C.
The phenotype of normal, reactive and malignant plasma cells Identification of 'many and multiple myelomas' and of new targets for myeloma therapy.
Haematologica 91:1234-1240(2006)
PubMed=17171682; DOI=10.1002/gcc.20404
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Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yua
【求助】骨髓瘤细胞的体内接种问题 参与者:qj_82 请教各位:骨髓瘤细胞如果要进行乳鼠或者大鼠的体内接种,是采用腹腔注射,还是皮下注射?还是直接注射在脾脏上?细胞密度要达到多少才有比较理想的接种效果? 参与者:zhangzhanli2008 皮下1*10的7次方-3*10的7次方/ml 腹腔1*10的6次方/ml
1、脾细胞和骨髓瘤细胞一般按2:1-5:1的密度混合,有的报道可以到10:1,不过总体来说我们常选3:1-5:1,记住,原则是脾细胞的数量比骨髓瘤的多。2、融合前,一般用HAT培养基做饲养细胞铺板,这是融合前的准备工作,因为饲养细胞分泌的某些细胞因子有助与融合的杂交瘤细胞生长,并且提供一定的细胞密度。通常是可以融合前一天做饲养细胞,老鼠选ICR或是BALB/C与ICR杂交的鼠,一只老鼠可以铺2-3块96孔板。3、我们融合选用96孔细胞培养板。融合时将脾细胞与骨髓瘤混合后离心,然后用手掌稍稍搓
骨髓瘤细胞能产生并分泌大量的免疫球蛋白,这样的瘤细胞融合后,可能影响或降低所分泌抗体的滴度,所以必须选育出非分泌免疫球蛋白缺陷型的骨髓瘤细胞。 选择骨髓瘤细胞的条件:①该瘤细胞系的来源应与制备脾细胞小鼠为同一品系,以便两者的组织相容性抗原一致;②骨髓瘤细胞必须是静息状态,不产生γ球蛋白或不分泌到细胞外;③骨髓瘤细胞生长需要一个较高的细胞密度,最好106个细胞/ml;④生长速度快,繁殖时间短。 目前常用的Balb/c小鼠产生的骨髓瘤细胞株有:①S194/5XXO・BU・1;②SP2/
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