In Vitro: Tricin 7-O-β-D-glucopyranoside (4-64 µM; 12 h) induces apoptosis in a dose-dependent manner after oxygen-glucose deprivation for 3 h followed by 12 h incubation in SH-SY5Y cells. Tricin 7-O-β-D-glucopyranoside (16, 32 µM; 12 h) decreases the expression of TNF-α (20 ng/ml for 30 min) induced phosphor-κB-α, phosphor-NF-κB, HMGB1 in SH-SY5Y cells.
In Vivo: Tricin 7-O-β-D-glucopyranoside (50, 100, 200 and 400 mg/kg; p.o.) shows neuroprotective potential in rats with ischemia and reperfusion (I/R).