8周龄野化鼠750和C57BL/6JGpt同步进行普通饲料(CD: Chow diet)和西方饲料(WD: Western diet)喂养。在喂养6周、10周、14周和18周时进行血脂检测,野化鼠750在正常饲料喂养下出现自发胆固醇(Chol、LDL-C)升高,在西方饮食(Western diet)诱导下,胆固醇水平上升更为明显,并明显高于B6J喂养西方饮食组。
4.正常饲料和Western Diet饲料喂养下的肝脏病理情况
8周龄野化鼠750和C57BL/6JGpt同步进行普通饲料(CD: Chow diet)和西方饲料(WD: Western diet)喂养。在喂养6周、10周、14周和18周时分别进行肝脏病理检测。结果显示,WD喂养6周后,野化鼠750出现明显的脂肪肝,喂养14周后发展为NASH,表型比C57BL/6JGpt更明显。
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