重组人 L1CAM 蛋白 (Fc 标签)

规格/价格
100 µg：3870
1 mg：25190

L1CAM Protein, Human, Recombinant (hFc Tag), HPLC-verified: 产品信息

• 纯度：≥ 90 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
• 内毒素：< 1.0 EU per μg protein as determined by the LAL method.
• 生物活性：Testing in progress
• 蛋白构建：A DNA sequence encoding the Human L1CAM (NP_000416.1) (Met1-Glu1120) was expressed with the Fc region of human IgG1 at the C-terminus.
• 表达宿主：HEK293 Cells
• 种属：Human
• 预测 N 端：Ile 20
• 分子量：The recombinant Human L1CAM consists of 1339 amino acids and predicts a molecular mass of 149.93 kDa. It migrates as an approximately 198.63 kDa band in SDS-PAGE under reducing conditions.
• 缓冲液：

1. Lyophilized from sterile PBS, pH 7.4.
2. Please contact us for any concerns or special requirements.
3. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
4. Please refer to the specific buffer information in the hard copy of CoA.
5. 运输方式：In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
6. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

• 稳定性 & 储存条件：

1. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
2. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

• 复溶：A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.

L1CAM Protein, Human, Recombinant (hFc Tag), HPLC-verified: 别称
CAML1 Protein, Human; CD171 Protein, Human; HSAS Protein, Human; HSAS1 Protein, Human; MASA Protein, Human; MIC5 Protein, Human; N-CAM-L1 Protein, Human; N-CAML1 Protein, Human; NCAM-L1 Protein, Human; S10 Protein, Human; SPG1 Protein, Human

L1CAM 背景信息
L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan, and integrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait, and adducted thumbs), and spastic paraplegia syndrome. Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate, and promoted cell transformation and tumorigenicity. Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy.