D-685,2893801-00-6

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D-685

CAS No. : 2893801-00-6

MCE 国际站：D-685

产品活性：D-685 是 D-520 的前体药物，在血脂化的帕金森病 (PD) 动物模型中表现出比母体 D-520 更高的体内抗帕金森病功效。D-685 减少人α-突触核蛋白 (α-syn) 蛋白的积累，表现出较强的大脑透过性。

研究领域：Neuronal Signaling

作用靶点：α-synuclein

In Vivo: D-685 (12 mg/kg; intraperitoneally daily for 1 month) reduces the accumulation of α-synuclein in α-Syn tg mice.
D-685 (10 μmol/kg; ip) is not only highly efficacious in reversing akinesia in male and female Sprague-Dawley rats weighing 220-225 g, compared to Reserpine (HY-N0480; 5.0 mg/kg; SC) alone, but also demonstrates significant enhancement of locomotion for the entire duration of the 6 h study.
D-685 exhibits facile penetration into the brain under ip administration with a high brain-to-plasma ratio (B/P: 4).

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