Nedosiran奈多西兰,2266591-83-5

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Nedosiran

CAS No. : 2266591-83-5

MCE 国际站：Nedosiran

产品活性：Nedosiran (DCR-PHXC) 是一种靶向乳酸脱氢酶 (LDH) 的 RNA 干扰剂 (RNAi)。Nedosiran 可用于研究并发终末期肾病 (ESRD)的原发性高草酸尿症 (PH)。Nedosiran 是一种 GalNAc-dsRNA 偶联物。

研究领域：Epigenetics

作用靶点：Small Interfering RNA (siRNA)

In Vitro: Nedosiran (DCR-PHXC) is an investigational ribonucleic acid interference (RNAi) therapy.
Nedosiran is a synthetic, double-stranded RNA oligonucleotide (i.e., small interfering RNA [siRNA]) designed to target the mRNA encoding LDHA.

In Vivo: Nedosiran is a RNAi therapy for primary hyperoxaluria that selectively reduce hepatic expression of lactate dehydrogenase.
Nedosiran specially inhibits hepatic expression of lactate dehydrogenase (LDHA).
Nedosiran is a double-strand siRNA molecule that is conjugated with GalNAc, which takes advantage of the aforementioned unique asialoglycoprotein receptor (ASGPR) delivery system in the liver. Nedosiran is administered by monthly subcutaneous injection. Nedosiran decreases plasma oxalate in animal models.

相关产品：Inclisiran  |  Givosiran  |  Lumasiran  |  Patisiran sodium  |  SiRNA Negative Control  |  Cemdisiran  |  Vutrisiran  |  AS-Patisiran  |  Fitusiran  |  GalNAc unconjugated/naked Inclisiran  |  Tivanisiran  |  Fazirsiran  |  GalNAc unconjugated/naked Fitusiran sodium  |  Teprasiran  |  AB-729 sodium  |  ATU027  |  ATU027 sodium  |  Bamosiran  |  Bamosiran sodium  |  Bevasiranib  |  Cimdelirsen  |  Elebsiran  |  Elebsiran sodium  |  Lumasiran sodium  |  Manusiran  |  Manusiran sodium  |  Olpasiran sodium  |  PF-04523655

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds