Benzalkonium苯扎氯铵,8001-54-5

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Benzalkonium chloride

CAS No. : 8001-54-5

MCE 国际站：Benzalkonium chloride

产品活性：Benzalkonium chloride 是一种有效的抗菌剂，在滴眼液中用作防腐剂。

研究领域：Anti-infection

作用靶点：Bacterial

In Vitro: Benzalkonium chloride (0.0001%-0.5%) results in a dose-dependent cytotoxicity in cells. Benzalkonium chloride also shows cytotoxicity against human keratinocytes, with 50% loss of viability of 4 μM. Benzalkonium chloride shows different results in NHEK and NB1RGB cell cultures, and the ED₅₀ of 3.9 and 62 μM, respectively. The clinically used concentration (0.01% Benzalkonium chloride) significantly reduces cell viability, with only 14%-19% of nasal epithelial cells surviving the treatment.

In Vivo: Benzalkonium chloride (0.02%) causes no abnormalities in the nasal epithelium of the monkeys after light and electron microscopical examination. In 4-5 week-old SD rats, 0.01% and 0.1% Benzalkonium chloride induce a time-dependent increase in the thickness of the nasal respiratory epithelium.

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