NR2F1 agonist 1,374101-64-1

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NR2F1 agonist 1

CAS No. : 374101-64-1

MCE 国际站：NR2F1 agonist 1

产品活性：NR2F1 agonist 1 是一种核受体 NR2F1 激动剂，可特异性激活恶性细胞的休眠程序。NR2F1 agonist 1 上调 NR2F1 和调节休眠的下游靶基因。NR2F1 agonist 1 通过 NR2F1 激活在头颈部鳞状细胞癌 (HNSCC) 中诱导神经嵴样生长抑制。NR2F1 agonist 1 在小鼠原发肿瘤模型中抑制肿瘤生长。

研究领域：Others

作用靶点：Others

In Vitro: NR2F1 agonist 1 (compound C26) (0.5 μM, 1 μM; 18 h) significantly induces luciferase expression in D-HEp3 cells.
NR2F1 agonist 1 (0.5 μM; 7 d) significantly down-regulates the phosphoinositide 3-kinase (PI3K) signaling pathway.
NR2F1 agonist 1 (0.5 μM; 7 d) significantly up-regulates mRNA levels of SOX9, RARβ, and p27.
NR2F1 agonist 1 (0.5 μM; 48 h) induces cell cycle arrest at G0/G1 in D-HEp3 cells.

In Vivo: NR2F1 agonist 1 (0.5 mg/kg/day; i.p.; 3 weeks) inhibits inhibits primary tumor growth and metastatic growth in lungs in mouse models.

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