ALX-5407,200006-08-2

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ALX-5407 hydrochloride

CAS No. : 200006-08-2

MCE 国际站：ALX-5407 hydrochloride

产品活性：ALX-5407 ((R)-NFPS) hydrochloride 是一种选择性、具有口服活性的甘氨酸转运体 GlyT1 抑制剂，IC₅₀ 值为 3 nM。ALX-5407 hydrochloride 可用于研究 N-methyl-D 天冬氨酸受体功能与精神分裂症。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：GlyT

In Vitro: ALX-5407 hydrochloride (0-1 mM) GlyT1- or GlyT2-dependently inhibits glycine transport and blocks [³H]glycine uptake in rat brain and QT6-1C cells with an IC₅₀ value of 3 nM.
ALX-5407 hydrochloride (50 nM) shows slow dissociation kinetics in QT6-1C cells.

In Vivo: ALX-5407 hydrochloride (1 and 10 mg/kg; oral administration, once) increases free glycine levels in rat prefrontal cortex.

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