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- SIGMA
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- SML0897-5MG
- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
2-8°C
- 保质期：
见瓶身
- 英文名：
ALX 5407 Hydrochloride
- 库存：
999
- 供应商：
麦飞生物
- CAS号：
200006-08-2
- 规格：
5MG
说明
应用
ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs).[1] It has also been used as a GlyT1 inhibitor to treat developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function.[2]
生化/生理作用
ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC50 values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC50 > 100 mM).
特点和优势
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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文献和实验N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn.
Hyo-Jin Jeong et al.
British journal of pharmacology, 161(4), 925-935 (2010-09-24)
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