Pozelimab帕泽利单抗帕泽利单抗,2096328-94

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Pozelimab

CAS No. : 2096328-94-6

MCE 国际站：Pozelimab

产品活性：Pozelimab (REGN3918) 是一种人 IgG4 抗 component 5 C5 单克隆抗体。Pozelimab 高亲和力的结合 C5 和 C5 变体，阻断补体介导的溶血。Pozelimab 可用于补体介导疾病的研究。

研究领域：Immunology/Inflammation

作用靶点：Complement System

In Vitro: Pozelimab binds with human C5 and cynomolgus monkey C5 with K_d values of 262 pM and 8.55 nM, respectively at 37˚C, pH7.4.
Pozelimab blocks classic pathway (CP)-mediated hemolysis in normal human and cynomolgus monkey serum with IC₅₀ values of 2.8 and 20 nM, respectively at 37˚C, pH7.4.
Pozelimab blocks alternative pathway (AP)-mediated hemolysis in normal human and cynomolgus monkey serum with IC₅₀ values of 26 and 8.9 nM, respectively at 37˚C, pH7.4.
Pozelimab binds to human C5, cynomolgus monkey C5, human R885C C5 and human C5b,6 with K_d values of 0.189, 2.73, 0.422, 0.465 and 0.137 nM respectively at 25˚C, pH7.4.

In Vivo: Pozelimab (15 mg/kg; s.c., once) has a prolonged pharmacokinetic (PK) with a half-life of approximately 13 days in male and female C5^hu/hu mice.

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