- ￥960
- Solarbio
- 北京
- K111540P
- 2025年07月16日
- WB
- Rabbit
- Human;Mouse;Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
A synthetic peptide of human EPHB1/EPHA2
- 亚型：
IgG
- 形态：
液体
- 保存条件：
-20℃
- 克隆性：
Polyclonal Antibody
- 适应物种：
Human;Mouse;Rat
- 保质期：
1年
- 库存：
888
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
WB
- 靶点：
EPHB1/EPHA2
- 规格：
50ul
产品简介
| 英文名称 | Anti-EPHB1/EPHA2 Polyclonal Antibody |
| 靶标 | EPHB1/EPHA2 |
| 别名 | ELK;EPHT2;Hek6;NET |
| 背景资料 | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). |
| Swiss Prot | P54762/P29317 |
| Gene ID | 2047/1969 |
| 亚细胞定位 | Cytoplasm Cell membrane/Cell membrane |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal Antibody |
| 亚型 | IgG |
| 预测交叉反应 | Chicken;Xenopus laevis |
| 蛋白分子量 | 27/64/110kDa |
| 稀释比例 | WB 1:1000-3000. |
| 免疫原 | A synthetic peptide of human EPHB1/EPHA2 |
| Public Immunogen Range | 610-660/976aa |
| 纯化方法 | Octanoic acid-ammonium sulfate precipitation |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 交叉反应 | Human;Mouse;Rat |
| 应用 | WB |
| 规格 | 50ul 100ul |
| 单位 | 支 |
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示：
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图
Western blot analysis with EPHB1/EPHA2 antibody diluted at 1:2000;Lane: U-251MG.
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文献和实验Polyclonal Antibody Production
, if desired this is best accomplished by Protein A Affinity Chromatography. 上一篇：make an Antibody against a Peptides 下一篇：Immunization Protocol for Monoclonal Antibody Production
Polyclonal Antibody Production
Polyclonal Antibody Production Very useful for rapid and simple generation of antibodies for western blots, ELISA assays, and immunoprecipitation. Rabbit Immunization Initial Preparation Your antigen
Construction of Polyclonal Antibody Libraries Using Phage Display
Polyclonal antibody libraries (PCALs) are standardized mixtures of antibodies (Abs) specific for an antigen (Ag) or multi-Ag target (a poly-Ag). As the immunoglobulin (Ig) genes are cloned, the mixtures can be perpetuated, amplified
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