重组人TNFRSF10D蛋白

重组人TNFRSF10D蛋白相关信息：

英文名称
Recombinant human TNFRSF10D protein, C-His-Avi (HEK293)
中文名称
重组人TNFRSF10D蛋白
英文别名
DcR2; Decoy receptor 2; CD 264; CD264; CD-264; DcR 2; decoy with truncated death domain; ID; TNF receptor related receptor for TRAIL; TNF related apoptosis inducing ligand receptor 4; TNFRSF 10D; TRAIL R4; TRAIL receptor 4; TRAIL receptor with a truncated death domain; TRAILR4; TRIALR 4; TRUNDD; Tumor necrosis factor receptor superfamily member 10d decoy with truncated death domain; Tumor necrosis factor receptor superfamily member 10D precursor; TR10D_HUMAN; Recombinant human TNFRSF10D protein, C-His-Avi (HEK293)
蛋白细胞定位
细胞膜
分子量
36
浓度
＞0.5 mg/ml
储存液
Lyophilized from 0.22 um filtered solution in PBS (pH=7.4) with 5 mM DTT. Normally 5% trehalose is added as protectant before Lyophilization.
保存条件
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.

重组人TNFRSF10D蛋白

背景资料：Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L, a member of the TNF family, induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was identified and designated DcR2. The DcR2 receptor is 386 amino acids in length and has an extracellular TRAIL binding domain, but lacks intracellular death domain and does not induce apoptosis. Although this receptor binds to the cytotoxic ligand TRAIL, it contains a truncated death domain and functions as an inhibitory receptor. When overexpressed, the DcR2 receptor can protect cells against TRAIL mediated cytotoxicity. Like DR4 and DR5, DcR2 transcript is widely expressed in a variety of normal human tissues but DcR2 is absent in most tumors. Ultraviolet radiation has been shown to upregulate DcR2 expression on human keratinocytes. Over expression of DcR2 attenuated TRAIL induced apoptosis.
DcR1因缺乏细胞内信号传导系统而不能传递凋亡信号,但能竞争性与TRAIL（肿瘤坏死因子相关凋亡诱导配体）结合,有干扰凋亡信号的传导作用。

重组人TNFRSF10D蛋白应用：仅供研究使用，不用于临床诊断！




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