Recombinant Murine IL-6
Catalog Number:
AF-216-16
Synonyms:
26 kDa protein, IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2
Description:
IL-6是一种多效细胞因子，在通过调节免疫及炎症反应来进行宿主防御的过程中发挥重要作用。IL-6由T细胞、单核细胞、成纤维细胞、内皮细胞及角质细胞产生，具有多种生物学功能。IL-6可以刺激B细胞分化和抗体产生，与IL-3一起协同增强巨核细胞的发育和血小板的产生。IL-6还可诱导肝急性期蛋白的表达，以及调节骨代谢。IL-6通过IL-6受体系统传导信号，后者由IL-6R和gp130两条链组成。小鼠IL-6对人的细胞没有活性，而人和小鼠的IL-6对小鼠细胞具有同等活性。重组小鼠IL-6是分子量为21.7 kDa的蛋白，由188个氨基酸残基组成。生产过程中的所有试剂均为非动物源性。
AA Sequence:
MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to stimulate the proliferation of mouse 7TD1 cells. The expected ED50 is ≤ 0.02 ng/ml, corresponding to a specific activity of ≥ 5 x 107 units/mg.
Cross Reactivity:
Monkey, Mouse, Rat, Human + Mouse, Mouse + Bacteria
Country of Origin:USA
技术资料