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- SIGMA
- 美国
- I5784-10mg
- 2025年07月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
瓶身
- 保质期：
coa
- 英文名：
SIGMA
- 库存：
999
- 供应商：
麦格生物
- CAS号：
138844-81-2
- 规格：
I5784-10mg
说明
应用
Ibandronate sodium salt has been used to study its effect on the proliferation and ultrastructure of Leishmania and Giardia by the generation of concentration curves.[1] It has also been used to elucidate the route by which nitrogen-containing bisphosphonates (N-BPs) enter the cytosol and inhibit their molecular target.[2]
生化/生理作用
Ibandronate is a nitrogen-containing bisphosphonate (N-BP).[1] It potentially inhibits mevalonate pathway in osteoclasts. Thus, ibandronate is effectively used to treat osteoporosis and other bone-related diseases.[2]
Ibandronate sodium inhibits farnesyl diphosphate synthase (IC50 = 20 nM). Ibandronate sodium is also a bone resorption inhibitor. It has been investigated for in vitro anti-tumor effects, such as apoptosis induction, inhibitor of cell growth, inhibition of invasive behavior, and inhibition of angiogenesis and for its in vivo role in various cancers including breast and prostate cancers.
特点和优势
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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文献和实验Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates
Yu Z, et al.
eLife, 7, e36620-e36620 (2018)
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