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- 详细信息
- 技术资料
- 亚型:
IgG
- 形态:
液体
- 保存条件:
-20℃
- 克隆性:
多克隆
- 标记物:
无
- 适应物种:
HMR
- 保质期:
一年
- 抗原来源:
兔
- 供应商:
万类生物
- 宿主:
兔
- 应用范围:
WB, IHC
- 浓度:
>1 mg/ml
- 靶点:
eIF2α
- 抗体英文名:
eIF2α antibody
- 抗体名:
eIF2α 抗体
- 规格:
50μl(>50μg)
产品概述
EIF2α is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes. eIF2α, also known as EIF2S1 or EIF2, is a 315 amino acid subunit of the eukaryotic initiation complex that functions to bind tRNA to the 40S ribosomal subunit (in a GTP-dependent manner), thereby initiating translation. Phosphorylation of the eukaryotic initiation factor 2 (eIF2) α subunit is a well-documented mechanism to downregulate protein synthesis under a variety of stress conditions.When eIF2αis not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2αis stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.
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