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- 详细信息
- 文献和实验
- 技术资料
- 亚型:
IgG
- 形态:
液体
- 保存条件:
-20℃
- 克隆性:
多克隆
- 标记物:
无
- 适应物种:
HMR
- 抗原来源:
兔
- 供应商:
万类生物
- 宿主:
兔
- 应用范围:
WB,IHC
- 抗体英文名:
Caspase-8 antibody
- 规格:
50μl(>50μg)
Caspase 8 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Initiator caspases, which include caspase8, activate effector caspases by cleaving inactive forms of effector caspases.Caspase-8, which is a heterodimer consisting of two subunits (p18 and p10), is widely expressed, but is detected at highest levels in peripheral blood leukocytes (PBLs), thymus, liver and spleen. Defects in CASP8, the gene encoding for caspase-8, may cause CASP8D (caspase-8 deficiency disorder), which is characterized by splenomegaly and CD95-induced apoptosis of PBLs, may lead to immunodeficiency due to defects in T lymphocyte, NK cell and B lymphocyte activation.
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文献和实验dali321 在Bid 诱导的caspase-8 活化中 高浓度的药物中caspase-8蛋白的表达是增多还是减少 右翼天使 在Bid 诱导的caspase-8 活化中 高浓度的药物中caspase-8蛋白的表达是增多 casgene 不受影响。 本文由丁香园论坛提供,想了解更多有用的、有意思的前沿资讯以及酷炫的实验方法的你,都可以成为师兄的好伙伴 师兄微
Quantification of Active Caspase-3 and Active Caspase-8 in Microglia Cells
During microglia activation the levels of active caspase-3, caspase-7 and caspase-8 are increased, which leads to the transcription of proinflammatory cytokines and factors. As such, the induction of caspase activity in microglia can be used
赐教!! lwjssry 要排除死亡受体途径检测一下caspase-8,如果caspase-8没有激活就可以了 月朗渔 谢谢! 我还想问下caspase-8、caspase-9和caspase-3如何检测?在这方面我还是新手,对于各种检测方法还比较陌生,不知道哪种方法更好些? lwjssry 用western或者用活性检测试剂盒。 月朗渔 好的,谢谢!
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