BAP1-IN-1,353495-21-3

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BAP1-IN-1

CAS No. : 353495-21-3

MCE 国际站：BAP1-IN-1

产品活性：BAP1-IN-1 (Compound 8) 是一种 BRCA1 相关蛋白 1 (BAP1) 催化活性抑制剂，其 IC₅₀ 为 0.1-1 μM。

研究领域：Others

作用靶点：Others

In Vitro: BAP1-IN-1 (Compound 8) (1 μM; 30 min) specifically inhibits BAP1 not just in vitro but also within the cellular context.
BAP1-IN-1 (0.1 μM; 24 h) significantly alters 240 genes in BAP1-WT cells, whereas only 33 transcripts are changed in BAP1-KO cells, demonstrating that the gene expression changes mainly depend on the presence of BAP1 protein.
BAP1-IN-1 (0-10 μM; 72 h) selectively inhibits cells with ASXL1 GOF mutations.

In Vivo: BAP1-IN-1 (Compound 8) (50 mg/kg/d; i.p.; 4 weeks) delays the progression of ASXL1-mutant leukemia and improves survival in mice.

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