Zilovertamab vedotin

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Zilovertamab vedotin

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MCE 国际站：Zilovertamab vedotin

产品活性：Zilovertamab vedotin (VLS-101) 是一种新型抗体-活性分子偶联物 (ADC)，包含人源化单克隆抗体 zilovertamab 和抗微管细胞毒素单甲基 vedotin。Zilovertamab vedotin 与肿瘤细胞 ROR1 结合导致快速内化、转运至溶酶体、抗体-活性分子偶联物裂解和单甲基 vedotin 释放。Zilovertamab vedotin 诱导细胞凋亡。Zilovertamab vedotin 可用于癌症研究。

研究领域：Antibody-drug Conjugate/ADC Related  |  Apoptosis

作用靶点：Antibody-Drug Conjugates (ADCs)  |  Apoptosis

In Vitro: Zilovertamab vedotin (VLS-101; 0-100 μg/mL) induces cytotoxicity in ROR1⁺ primary MCL cells in a dose-dependent manner.
Zilovertamab vedotin (24h; ibrutinib-sensitive (JeKo-1) and resistant (JeKo BTK KD_2) cell lines) induces cell apoptosis and cell cycle arrest at G2/M.

In Vivo: Zilovertamab vedotin (VLS-101; 2.5 mg/kg; i.v.; weekly, for 3 weeks) targets ROR1-expressing PDX models with dual resistance to ibrutinib and CAR T. A PDX model. Zilovertamab vedotin inhibits tumor growth.

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