Lerdelimumab乐德木单抗乐德木单抗,285985-

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Lerdelimumab

CAS No. : 285985-06-0

MCE 国际站：Lerdelimumab

产品活性：Lerdelimumab (CAT-152) 是一种人 IgG4 抗 TGF-β2 重组单克隆抗体。Lerdelimumab 可作为青光眼的抗结疤剂用于研究。

研究领域：Stem Cell/Wnt  |  TGF-beta/Smad

作用靶点：TGF-beta/Smad

In Vitro: Lerdelimumab (10 μg/mL) inhibits all TGF-β2-induced effects. TGF-β2 stimulates transdifferentiation and contraction of the capsular bag and induces MMP-2 and -9 release of capsular bags.

In Vivo: Lerdelimumab (100 μL, 1 mg/mL; subconjunctival injection; on days 2, 3, 4, 7, 9, 11 and 14 after surgery) significantly improves glaucoma surgical outcome and reduces the risk of corneal side effects.

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