Geptanolimab杰洛利单抗杰洛利单抗,2348469

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Geptanolimab

CAS No. : 2348469-43-0

MCE 国际站：Geptanolimab

产品活性：Geptanolimab (CBT-501) 是一种针对程序性死亡-1 (PD-1) 的人源化 IgG4k 单克隆抗体。Geptanolimab 通过竞争作用抑制 PD-L1/L2 与 PD-1 的结合。Geptanolimab 可用于癌症研究。

研究领域：Immunology/Inflammation

作用靶点：PD-1/PD-L1

In Vitro: Geptanolimab (CBT-501) has highly specific binding to PD-1 of human (K_D=505 pM) and cynomolgus (K_D=7.2 nM).
Geptanolimab enhances human T-cell activation in the Mix Lymphocyte Reaction (MLR), increasing release of IL-2 and INF-γ.

In Vivo: Geptanolimab (ip; once every two weeks, for 6 weeks; mice with MC38 syngeneic tumor models) has anti-tumor activity and tumor inhibition rate reached 83%.

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