In Vitro: RO5461111 (16 h) 在 人 (RAJI) 或鼠 (A20) 细胞系中具有细胞活性,显著降低了脾脏树突状细胞的活化以及随后 CD4 T 细胞和 CD4/CD8 双阴性 T 细胞的扩增和活化。
In Vivo: RO5461111 (0.1-100 mg/kg; p.o.; single dose) suppresses T cell priming and antisheep IgG upon vaccination with sheep IgG in BALB/c mice. RO5461111 (1.31 mg/mouse or 30 mg/kg; p.o.; 8 weeks) disrupts germinal centres (as CXCL12) and reduces hypergammaglobulinemia and lupus autoantibody production F in MRL-Fas(lpr) mice. And RO5461111 reduces lung inflammation and improves lupus nephritis.