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- 2025年12月05日
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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥675.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥614.0 |
| 规格： | 10 mg | 产品价格： | ￥1000.0 |
| 规格： | 25 mg | 产品价格： | ￥1825.0 |
| 规格： | 50 mg | 产品价格： | ￥2850.0 |
| 规格： | 100 mg | 产品价格： | ￥4413.0 |
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PYR-41
CAS No. : 418805-02-4
MCE 国际站：PYR-41
产品活性：PYR-41 是一种选择性，可透过细胞的泛素活化酶 E1 抑制剂，IC50 值小于10 μM，对E2和E3基本无作用。
研究领域：Metabolic Enzyme/Protease | Apoptosis
作用靶点：E1/E2/E3 Enzyme | Apoptosis
In Vitro: PYR-41 increases total sumoylation in cells in addition to blocking ubiquitylation. PYR-41 attenuates cytokine-mediated nuclear factor-κB activation. PYR-41 also prevents the downstream ubiquitylation and proteasomal degradation of IκBα. Furthermore, PYR-41 inhibits degradation of p53 and activates the transcriptional activity of this tumor suppressor. PYR-41 (50 μM) promotes accumulation of ubiquitinated proteins. PYR-41 causes a concentration-dependent (10-50 μM) decline in DUB activity in Z138 cells after 4 h. PYR-41 potently inhibits USP5 DUB activity, even at the lowest concentration (10 μM). PYR-41 potently (10-50 μM) inhibits the activity of various DUBs, determined to represent USP9x, USP5, USP14, UCH37 and UCH-L3. Co-treatment of Z138 cells with DTT and PYR-41 completely abolishes the accumulation of ubiquitinated proteins.
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文献和实验Hints and precautions for the care, feeding and breeding of Neurospora
ascospores showing the segregation of two genes in a cross of col-4 x pyr-2. Spores were isolated on minimal agar medium in petri dishes, heated at 60° for 30 minutes for activation, and incubated at 25° for 18 hours. This nutritional mutant grows
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