The OrganoPlate® Graft is an advanced microfluidic tissue culture device that contains 64 independent tissue culture chips. The system is developed for grafting tissues to a vascular bed. Its open-top design makes it possible to receive target tissues for studying interaction with a vascular bed. It uniquely facilitates perfusion of the tissue and allows drug administration through the vasculature. The platform can be used for vascularization studies of various tissues in areas such as oncology and toxicology.
Each chip has one in-gel culture channel, two perfusion channels, and one open grafting chamber. The platform enables perfusion and addition of cells, compounds, and stimuli, and provides direct access to vascularized tissues. There is no membrane between the channels, as the channels are separated with PhaseGuideTM technology. A single chip is connected to 7 wells of the OrganoPlate® in a 3x3 well grid, with the central well providing a grafting chamber and viewing access. Any number of chips can be used in an experiment.