Anti-IFIH1 Polyclonal Antibody

产品简介

英文名称	Anti-IFIH1 Polyclonal Antibody
中文名称	含干扰素诱导解旋酶C域蛋白1抗体
靶标	IFIH1
别名	CADM-140 autoantigen, Clinically amyopathic dermatomyositis autoantigen 140 kDa, DEAD/H (Asp Glu Ala Asp/His) box polypeptide, DEAD/H box polypeptide, Helicard, Helicase with 2 CARD domains, Hlcd, IDDM 19, IDDM19, IFIH 1, Ifih1, IFIH1_HUMAN, Interferon induced helicase C domain containing protein 1, interferon induced with helicase C domain 1, Interferon induced with helicase C domain protein 1, Interferon-induced helicase C domain-containing protein 1, Interferon-induced with helicase C domain protein 1, MDA 5, MDA-5, Melanoma differentiation associated protein 5, Melanoma differentiation-associated gene 5, Melanoma differentiation-associated protein 5, MGC133047, Murabutide down regulated protein, Murabutide down-regulated protein, RH 116, RH116, RIG I like receptor 2, RLR 2, RNA helicase DEAD box protein 116, RNA helicase-DEAD box protein 116,
背景资料	Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Detects coronavirus SARS-CoV-2 (PubMed:24686847). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.
Swiss Prot	Q9BYX4
Gene ID	64135
亚细胞定位	Cytoplasm Nucleus
宿主	Rabbit
克隆类型	Polyclonal Antibody
亚型	IgG
蛋白分子量	25/117kDa
稀释比例	WB 1:1000-3000;IHC 1:100-300.
免疫原	A synthetic peptide of human IFIH1
Public Immunogen Range	550-600/1025aa
纯化方法	Affinity purification
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
保存	Store at -20°C. Avoid freeze / thaw cycles.
交叉反应	Human;Mouse
应用	WB;IHC
规格	50ul 100ul
单位	支

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示：
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图

Western blot analysis with IFIH1 antibody diluted at 1:2000;Lane: Mouse liver.

Immunohistochemistry of paraffin-embedded Human colorectal cancer with IFIH1 antibody diluted at 1:200.

Immunohistochemistry of paraffin-embedded Human renal cancer with IFIH1 antibody diluted at 1:200.

Immunohistochemistry of paraffin-embedded Human thyroid cancer with IFIH1 antibody diluted at 1:200.