Anti-PSTPIP1 Polyclonal Antibo

产品简介

单位	支
英文名称	Anti-PSTPIP1 Polyclonal Antibody
别名	CD2BP1;CD2BP1L;CD2BP1S;H-PIP;PAPAS;PSTPIP
宿主	Rabbit
稀释比例	WB 1:500-2000. IHC 1:50-200.
Gene ID	9051
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	O43586
蛋白分子量	48kDa
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
亚细胞定位	Cell projection Cleavage furrow Cytoplasm cytoskeleton lamellipodium perinuclear region uropodium
免疫原	Recombinant protein of human PSTPIP1
亚型	IgG
性状	液体
纯化方法	Affinity purification
背景资料	This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.
Public Immunogen Range	Recombinant protein of human PSTPIP1
克隆类型	Polyclonal Antibody
交叉反应	Human Rat Mouse
应用	WB IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示：
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图

Western blot analysis with PSTPIP1 antibody diluted at 1:1000

Immunohistochemistry of paraffin-embedded human stomach using PSTPIP1 antibody at dilution of 1:100 (x40 lens).