Anti-RSPO2 Polyclonal Antibody

产品简介

英文名称	Anti-RSPO2 Polyclonal Antibody
中文名称	R-spondin 2同源蛋白抗体
靶标	RSPO2
别名	R-spondin-2;Roof plate-specific spondin-2;hRspo2;UNQ9384/PRO34209;CRISTIN2; RSPO2_HUMAN; R spondin 2; R spondin 2 homolog; R-spondin 2 homolog (Xenopus laevis); R-spondin family, member 2;
背景资料	Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed:29769720).
Swiss Prot	Q6UXX9
Gene ID	340419
亚细胞定位	Cytoplasm
宿主	Rabbit
克隆类型	Polyclonal Antibody
亚型	IgG
预测交叉反应	Bovine;Zebrafish
蛋白分子量	20/21/28kDa
稀释比例	IHC 1:50-200.
免疫原	Recombinant protein of human RSPO2
Public Immunogen Range	1-177aa
纯化方法	Octanoic acid-ammonium sulfate precipitation
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
保存	Store at -20°C. Avoid freeze / thaw cycles.
应用	IHC
规格	50ul 100ul
单位	支

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示：
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图

Immunohistochemistry of paraffin-embedded human ovarian cancer with RSPO2 antibody diluted at 1:100.