Anti-CASP4 Polyclonal Antibody

产品简介

英文名称	Anti-CASP4 Polyclonal Antibody
中文名称	胱天蛋白酶4抗体
别名	ICE(rel)II;ICEREL-II;ICH-2;Mih1;Mih1/TX;TX;caspase-4
背景资料	Inflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators. Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection. In later stages of the infection, LPS from cytosolic Salmonella triggers CASP4 activation, which ultimately results in pyroptosis of infected cells and their extrusion into the gut lumen, as well as in IL18 secretion. Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation. Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity. Involved in cell death induced by endoplasmic reticulum stress and by treatment with cytotoxic APP peptides found Alzheimer's patient brains. Activated by direct binding to LPS without the need of an upstream sensor. Does not directly process IL1B. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation.
Swiss Prot	P49662
Gene ID	837
亚细胞定位	Cytoplasm Cell membrane
宿主	Rabbit
克隆类型	Polyclonal Antibody
亚型	IgG
蛋白分子量	13/18/30/36/43kDa
稀释比例	WB 1:1000-3000. IHC 1:50-200.
免疫原	A synthetic peptide of Human CASP4
Public Immunogen Range	55-105/377aa
纯化方法	Affinity purification
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
保存	Store at -20°C. Avoid freeze / thaw cycles.
交叉反应	Human Rat Mouse
应用	WB IHC
规格	50ul 100ul
单位	支

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
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使用前请离心。如有问题请及时联系我们。
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