PTP1B-IN-2

PTP1B抑制剂(IC50=50nM)；对PTP1B具有选择性，优于TCPTP、SHP-1、SHP-2和LAR（IC50分别为760、2,450、2,160和12,610nM）；可增强L6肌管中胰岛素诱导的葡萄糖摄取，摄取量从5µM增加到20µM。A PTP1B inhibitor (IC50 = 50 nM); selective for PTP1B over TCPTP, SHP-1, SHP-2, and LAR (IC50s = 760, 2,450, 2,160, and 12,610 nM, respectively); enhances insulin-induced glucose uptake in L6 myotubes from 5-20 µM.分子式C34H36N2O9S2分子量680.8O=C(C1=CC(N(S(=O)(CC2=CC=CC=C2)=O)CC3=CC=C(N(S(=O)(C)=O)CC(OC)=O)C=C3)=CC=C1OCC4=CC=C(C)C=C4)OC