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BLM-IN-2
MCE 国际站：BLM-IN-2
产品活性：BLM-IN-2 是一种布鲁姆氏综合征蛋白 (BLM) 抑制剂，其 IC50 值为 0.8 μM。BLM-IN-2 能有效抑制结直肠癌细胞的增殖、侵袭、细胞周期阻滞和凋亡。BLM-IN-2 可用于结直肠癌 (CRC) 的研究。
研究领域：Cell Cycle/DNA Damage | Apoptosis
作用靶点：DNA/RNA Synthesis | Apoptosis
In Vitro: BLM-IN-2 (0-20 μM) has good inhibitory effect on BLM unwinding and binding DNA with IC50 values of 0.8 μM and 2.3 μM, respectively.
BLM-IN-2 exhibits the potent BLM-dependent cytotoxicity against the CRC cells but weak against normal cells.
BLM-IN-2 (3 μM; 48 h) disrupts the HRR level while inhibiting BLM located on the DSB site and trigger DNA damage in the CRC cells.
BLM-IN-2 (0-5 μM; 48 h) effectively suppresses the proliferation and invasion of CRC cells, along with cell cycle arrest and apoptosis.
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文献和实验of T-cell activation: CD2, CD3D, CD3E, CD3G, CD4, CD7, CD80, CD86, CD8A, CD8B1, CLECSF12, ICOSL, IRF4, KIF13B, NCK1, NCK2, PRLR, SIT, SLA2, TNFSF14. T-cell proliferation: CD28, CD3E, GLMN, ICOSL, IL10, IL12B, IL18, IL27, NCK1, NCK2, SFTPD, SPP
【精华】vol 687 Chapter 3 采用Splinkerette-PCR技术对前病毒基因组插入位点进行分离
retroviralinsertional mutagenesis in Blm-deficient mice. Embo J 25, 3422–31. 8. Suzuki, T., Shen, H., Akagi, K., Morse, H. C.,Malley, J. D., Naiman, D. Q., Jenkins, N. A.,and Copeland, N. G. (2002) New genes involved in cancer identified by retroviral tagging. Nat
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