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- 2025年12月05日
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HDAC-IN-49
MCE 国际站：HDAC-IN-49
产品活性：HDAC-IN-49 是一种有效的非选择性 HDAC (HDAC) 抑制剂，对 HDAC1、HDAC2、HDAC3、HDAC4 和 HDAC6 的 IC50 分别为 13 nM、14 nM、21 nM、1880 nM 和 10 nM 。HDAC-IN-49 表现出显着的抗白血病活性， 但对健康细胞具有低细胞毒性。
研究领域：Cell Cycle/DNA Damage | Epigenetics
作用靶点：HDAC
In Vitro: HDAC-IN-49 (compound 10h) shows remarkable cytotoxic potential against different therapy-resistant leukemia cell lines, with IC50 values of 0.375 μM, 0.218 μM, and 0.285 μM for HAL01, HL60 and Jurkat cells, respectively.HDAC-IN-49 (compound 10h; 1-5 μM; 48 h) treatment results in a significant apoptosis induction in HL60 cells.
HDAC-IN-49 (compound 10h; 6-36 μM; 24 h) shows a dose-dependent increase in the level of acetylation of α-tubulin and histone 3 (H3) in HL60 cells.
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文献和实验CD49a/CD49b/CD49c/CD49d/CD49e/CD49f分子
CD49a/CD49b/CD49c/CD49d/CD49e/CD49f 分子 CD49a 常用单克隆抗体或代号： SR84,IB3.1;(VLAa 1) 主要表达细胞： Ta,Ba,M [AS] 分子质量(kDa)和结构： gp210,与CD29组成VLA- 1 功 能： 粘附CA和LM CD49b 常用单克隆抗体或代号： Gi94;(VLA- a 2,ECMR- Ⅱ,Pt- GPIa) 主要表达细胞： Leu,Pt,Fb,En [AS] 分子
Determining Ligand Specificity of Ly49 Receptors
Ly49 receptors in rodents, like KIR in humans, play an integral role in the regulation of NK cell activity. Some inhibitory Ly49 are known to interact with specific MHC I alleles to maintain tolerance to self tissues, and NK activation
embryonic stages. Moreover, the increase number of xenobiotic showing HDAC inhibitory activity recently focused the attention of teratologists on the possible role of HDAC inhibition as a novel teratogenic mechanism. This hypothesis has been demonstrated
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