Zanolimumab扎木单抗扎木单抗,652153-01-

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Zanolimumab

CAS No. : 652153-01-0

MCE 国际站：Zanolimumab

产品活性：Zanolimumab (Anti-Human CD4 Recombinant Antibody) 是一种人单克隆抗体，靶向 CD4。Zanolimumab 可有效抑制 T 细胞受体 (TCR) 的信号转导。Zanolimumab 可用于类风湿性关节炎、银屑病、黑色素瘤、皮肤和周围 T 细胞淋巴瘤的研究。

研究领域：Others

作用靶点：Others

In Vitro: Zanolimumab (10 and 100 ng/mL) shows strong killing of the CD4⁺ T cells with a better effect to CD45RO⁺ subset than the CD45RA⁺ subset.
Zanolimumab (1-10000 ng/mL) Fc and dose-dependently down-regulates the level of CD4 from purified primary CD4⁺ T cells and SUP-T1 T cells.
Zanolimumab (1-10000 ng/mL) potently inhibits of TCR-stimulated T-cell proliferation both in tetanus toxin induced and anti-CD3 induced T-cell proliferation.
Zanolimumab (0-30 min) inhibits TCR signal transduction.

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