Actoxumab阿克托舒单抗,1245634-25-6

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Actoxumab

CAS No. : 1245634-25-6

MCE 国际站：Actoxumab

产品活性：Actoxumab 是一种抗艰难梭菌毒素 A (C. difficile toxin A) 的抗毒素抗体，能够靶向并破坏 TcdA。Actoxumab 能够防止可以防止肠道壁的损伤和与艰难梭菌有关的炎症反应。Actoxumab 与靶向 TcdB 的 Bezlotoxumab (HY-P9929) 表现出良好的协同作用。

研究领域：Others

作用靶点：Others

In Vitro: Actoxumab (10 mg/kg WT or N297Q mutant (N297Q) actoxumab-bezlotoxumab; 2 h plus 24 h) significantly inhibits cell rounding activity in Vero cells under 2 ng/mL TcdA treatment.

In Vivo: Actoxumab (0.1-10 mg/kg or 50 mg/kg; i.p.; single dose) shows protective effect in multiple murine models of clostridium difficile infection (CDI), including systemic and local (gut) toxin challenge models, as well as primary and recurrent models of infection in mice.
Actoxumab shows a synergy with Bezlotoxumab, and (combination dosage of 3, 30, 300 μg/mouse; i.p.; single dose) prevents both epithelial damage and inflammatory disease.

相关产品：Digitonin  |  5-Ph-IAA  |  FLAG peptide  |  Tocofersolan  |  Monocrotaline  |  Lactate sodium  |  TCEP hydrochloride  |  3X FLAG peptide  |  DPPH  |  Pertussis Toxin  |  Pronase E (Activity ≥ 7000 U/g)  |  O-Propargyl-Puromycin  |  NMDI14  |  Phytohemagglutinin  |  MYLS22  |  Hyaluronidase  |  Biotinyl tyramide  |  Kifunensine  |  Human IgG1 kappa, Isotype Control  |  4-Azido-L-phenylalanine  |  6-Aminonicotinamide  |  Ammonium tetrathiomolybdate(VI)  |  OVA Peptide(257-264) TFA  |  Alkyne-phenol  |  Lauryl maltose neopentyl glycol  |  SHIN1  |  CHAPS  |  Cytosporone B

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds