Ulocuplumab乌洛鲁单抗乌洛鲁单抗,1375830-

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Ulocuplumab

CAS No. : 1375830-34-4

MCE 国际站：Ulocuplumab

产品活性：Ulocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338) 是一种完全人 IgG4 抗 CXCR4 抗体。Ulocplumab 诱导癌细胞凋亡 (apoptosis)，能够抑制 CXCL12 介导的慢性淋巴细胞白血病 (CLL) 细胞在 CXCR4 激活下的迁移。Ulocplumab 在急性髓系白血病 (AML)，非霍奇金淋巴瘤 (NHL) 和多发性骨髓瘤移植模型中显示抗肿瘤活性。

研究领域：GPCR/G Protein  |  Immunology/Inflammation

作用靶点：CXCR

In Vitro: Ulocuplumab (0-100 μM; 48 h) lacks antibody dependent cellular cytotoxicity (ADCC) or complement (CDC) activity, but also induces apoptosis mediated by CXCR4 binding in Ramos cells and CLL/cancer cell lines, also shows pro-apoptotic in primary leukemia cells from CLL patients.
Ulocuplumab (0.2 μM and 2 μM; 15 s) inhibits F-actin polymerization and reduces the peak response to CXCL12, and also (20 nM-2 μM; 1 h) inhibits cell migration.
Ulocuplumab (200 nM; 6 h) leads to induction of programmed cell death (PCD) is caspase independent.
Ulocuplumab (10 μg/mL; 4 h) induces cell death via production of reactive oxygen species (ROS) in CLL cells.
Ulocuplumab inhibits CXCL12-induced calcium flux with an EC₅₀ value of 10 nM in Ramos.

In Vivo: Ulocuplumab (3-30 mg/kg; i.p.; every 3-4 days for 5 doses; 65 days in total) inhibits tumor growth of multiple myeloma xenograft models in mice, including Ramos B cells, HL-60 cells, MOLP-8 cells, Nomo-1 cells, and JJN-3R cells models.

相关产品：Plerixafor  |  SB225002  |  AMG 487  |  Kynurenic acid  |  Reparixin  |  AZD8797  |  Navarixin  |  AZD-5069  |  Motixafortide  |  SCH 546738  |  TAK-779  |  SX-682  |  Decursin  |  Baohuoside I  |  NUCC-390 dihydrochloride  |  Mavorixafor trihydrochloride  |  NBI-74330  |  Ladarixin  |  ML 145  |  ML339  |  ACT-1004-1239  |  SB-265610  |  VUF11207 fumarate  |  CXCR7 antagonist-1  |  IT1t dihydrochloride  |  Danirixin  |  LY2510924  |  PS372424 hydrochloride

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds