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- 2025年07月16日
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-20°C, sealed storage, away from moisture and light
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
1 mg
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PZ703b hydrochloride
MCE 国际站：PZ703b hydrochloride
产品活性：PZ703b hydrochloride 是一种 Bcl-xl PROTAC 降解剂，可以诱导细胞凋亡 (apoptosis)，抑制癌细胞增殖。PZ703b hydrochloride 可用于膀胱癌的研究。
作用靶点：PROTACs | Apoptosis | Bcl-2 Family
In Vitro: PZ703b hydrochloride (0-1 μM, 24 h) synergistically inhibits bladder cancer cell proliferation with Mivebresib with a dose-dependent manner and induces apoptosis in bladder cancer cells via the mitochondrial pathway.
PZ703b hydrochloride (0-1 μM, 48 h) inhibits cell viability of MOLT-4 and RS4;11 cells with IC50 values of 15.9 and 11.3 nM, respectively.
PZ703b hydrochloride (10 nM, 48 h) induces rapid and durable BCL-XL degradation and apoptosis in MOLT-4 cells through the caspase-3 mediated pathway.
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文献和实验Guanidine Hydrochloride Purification of Proteins From SDS
Pepstatin A (2.0 mg/ml)10 ml Leupeptin (1.0 mg/ml)10 ml Aprotinin (5.0 mg/ml)(Protease Inhibitor Cocktail Sigma #P8340)Denaturation Buffer6 M guanidine hydrochloride 57.3 g G-HCl20 mM Hepes 7.9 2 ml 1M Hepes pH 7.910 mM KCl 0.074 g KCl0.5 mM DTT 100 ml 0.5 M
Guanidine Hydrochloride Purification of Proteins From SDS PAGE
(Sigma #P7626) 10 ml Pepstatin A (2.0 mg/ml) 10 ml Leupeptin (1.0 mg/ml) 10 ml Aprotinin (5.0 mg/ml) (Protease Inhibitor Cocktail Sigma #P8340) Denaturation Buffer 6 M guanidine hydrochloride 57.3 g G-HCl 20 mM Hepes 7.9 2 ml 1M Hepes pH 7.9 10 mM
Packed column subcritical and/or supercritical fluid chromatography (p-sub or pSFC) has been used as a powerful chiral separation technique, whereby a mobile phase produces low viscosity, a high diffusion coefficient, and a solvating power. P
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